胃癌是消化系統惡性腫瘤之一,據世界衛生組織統計,2020年胃癌分別居全球癌癥發病率和死亡率的第五位和第四位,在我國,胃癌發病率和死亡率分列所有惡性腫瘤的第四位和第三位1。我國胃癌患者確診時多為晚期(II-IV期),約占85%,早期(I期)僅占15.2%2,而晚期胃癌患者的五年總生存率仍不足50%3,其中IV期胃癌僅為9.1%?。但早期胃癌患者行根治性手術切除術后五年OS率超過 90%?,因此手術切除是實現胃癌根治和獲得長期生存的重要手段。然而約有2/3的患者在確診時為不可切除的胃癌?,因此,為該類患者爭取根治性手術機會對提升胃癌總體預后意義重大。近年來,隨著醫學科技進步,腫瘤治療不斷發展以及創新藥物的更迭出新,轉化治療進入大家的視野,旨在通過化療、靶向藥物治療、免疫治療等綜合治療手段,使初始不可切除的腫瘤轉化為R0可切除,從而延長進展期胃癌患者的生存期和提高其生活質量。
開疆拓土
晚期胃癌轉化治療探索之路
天降神兵
信迪利單抗胃癌勢如破竹
圖1 CO-STAR研究中,ORR,DCR,R0轉化率等數據
醫保傳福音惠及更多患者
參考文獻(向上滑動查看):
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撰寫:Julius
審校:Dreams
排版:Babel
執行:Faline
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